Just read up on Pon-E. If you were given the option to take a drug that would temporarily turn you into a pony of the opposite gender, would you take it? The cons are that it's highly addictive, withdraw involves teh feeling of phantom limbs and if you overdose, the change is permenant.

I’d probably do it. I mean hell I draw myself as Penny enough times.

The Pon-E drug would just be bringing everything to its natural extreme conclusion :U

Ace, rendered as Pone, now Penny.