What Ganon once had wasn’t a curse, it was a possession. He was the literal vessel for Demise, at least he was in my headcanon, but I’m trying to decide on whether or not Demise possessed him all on his own… or if he had devote followers who found the vessel for him.
If the latter, then Twinrova sisters could very well be the two who took Ganondorf away and forcibly made him to be Demise’s vessel as baby all those timelines ago. I can imagine a cult devoted to Demise with Twinrova as their leader, with a foothold in many places in Hyrule, including the political world.
But that had been timelines ago: the same cult is scattered and thought to have been dissolved for the most part in the current timeline, but with the way things will eventually take a turn, that belief will be proven wrong. o3o