I have a zero tolerance policy for transphobia in my youtube comments: if someone is maliciously transphobic even once then I not only remove their comment, I mute that user across my entire channel and add the transphobic term they used to the list of words that automatically mutes the comment. Since I started doing this I've noticed a MASSIVE improvement in my comments: like, the first video after I came out there was loads of transphobia, the second one less, the third one even less, and now it's been almost 24 hours and there's been like 10? This leads me to two related conclusions:

1) Transphobes aren't very original: they keep using the same stock phrases so it's very easy to filter them out

2) There aren't that many of them. It's just the same few hundred assholes every time.